032500000a22004690004500 292112 20240227120317.0 cr mn nnnaucua 051219s2005 nju g b 001 0 eng 2004013542 1588290271 (hardback) 9781588290274 (hardback) 9781588290274 (paperback) 9781588290274 (ebook) (Sirsi) 292112 UIAM eng rda eng RC271.C35 Camptothecins in cancer therapy / edited by Thomas G. Burke and Val R. Adams Totowa, N.J. : Humana Press, c2005 ©2005 xiii, 460 pages : illustrations ; 24 cm. text rdacontent unmediated rdamedia computer rdamedia volume rdacarrier online resource rdacarrier text file PDF rda Cancer drug discovery and development ; Includes bibliographical references and index. Mechanism of action of topoisomerase I poisons / Leroy F. Liu and Shyamal D. Desai -- Crystallographic insight into the mechanism of drug-induced topoisomerase I DNA damage / Alex B. Burgin, Jr., Bart L. Staker, and Lance Stewart -- Inhibitors of topoisomerase I function / Sidney M. Hecht -- Cytotoxic mechanisms of the topoisomerase I inhibitors / Yves Pommier ... [et al.] -- Biochemical and genetic analyses of DNA topoisomerase I-mediated DNA damage / Robert C.A.M. Van Waardenburg and Mary-Ann Bjornsti -- Preclinical models for evaluating topoisomerase-I targeted drugs / Aarti S. Juvekar ... [et al.] -- Mechanisms of resistance to camptothecins / Zeshaan A. Rasheed and Eric H. Rubin -- Recent advances in camptothecin drug design and delivery strategies / Thomas G. Burke ... [et al.] -- Clinical experience with 9-aminocamptothecin: lessons for new drug development / Chris H. Takimoto -- Clinical studies of rubitecan (9-nitro 20(s) camptothecin) / Hilary Hewes, Judith A. Smith, and Claire Verschraegen -- Irinotecan: current clinical status and pharmacological aspects / Laurent P. Rivory -- Clinical experience with topotecan / Aimee K. Bence and Val R. Adams -- The clinical development of lurtotecan: experience with water-soluble and liposomal forms / Keith T. Flaherty ... [et al.] -- Preclinical and clinical development of dx-8951f (exatecan mesylate): a hexacyclic camptothecin analog / Eric K. Rowinsky -- Camptothecins in the treatment of primary brain tumors / Clinton F. Stewart, Markos Leggas, and Henry S. Friedman -- Camptothecins in the treatment of lung cancer / Pankaj Kumar ... [et al.] -- Use of camptothecins in the treatment of leukemia and related disorders / Bejamin M.F. Mow and Scott H. Kaufmann. Also available in electronic resource. Camptothecin 20797 Cancer Chemotherapy 20798 Electronic books (Form) Burke, Thomas G., PhD, editor 20799 Adams, Val R., editor 20800 Cancer drug discovery and development 15302 https://link.springer.com/10.1385/1592598668 bib-nmz-ajt-kas lcc 209972 242031 0 0 0 0 GENERAL KIMC KIMC OPEN 2019-08-05 517.05 RC271C35C199A 2005 00000994679 2019-08-05 00:00:00 1 517.05 BOOKGEN 0 0 lcc 0 19 EBOOK IIUM IIUM WEB 2022-10-19 0 eb RC 271 C35 C199A 2005 11100446076 2022-10-19 00:00:00 2022-10-19 EBOOK