022460000a22003250004500 753840693 20250226062939.0 121119s2011 enka f b 001 0 eng c 9781849731607 (hbk.) UIAM eng QP517.C45 Extracellular and intracellular signaling / edited by James D. Adams, Jr., Keith K. Parker Cambridge, UK : RSC Pub., c2011 xiii, 303 p. : ill. (some col.) ; 24 cm. rdacontent rdamedia rdacarrier RSC drug discovery series ; no. 10. Includes bibliographical references and index. "Intracellular cell signaling is a well understood process. However, extracellular signals such as hormones, adipokines, cytokines and neurotransmitters are vital to the process and have been largely ignored in other works on signaling. They are causative agents in hypertension, diabetes, heart disease, arthritis and other diseases. Aimed at medical professionals and pharmaceutical specialists, this book integrates for the first time extracellular and intracellular signaling processes and offers a fresh perspective on new targets for drug development. With contributions from leading international authorities, it is the result of close cooperation between the authors of the various chapters. Readers are introduced to a new approach to disease causation by adipokines and toxic lipids. Heart disease, migraines, stroke, Alzheimer's disease, diabetes, cancer, and arthritis are approached from the perspective of toxic lifestyle and accumulation of toxic proteins and lipids. Evidence is presented that by alterations in toxic lifestyles you can reduce the incidence of such diseases. New therapeutic targets involving adipokines, ceramide and endocannabinoids are also discussed."--Back cover. Cellular signal transduction 19936 Cell interaction 22257 Drug development 4831 Adams, J. D. (James D.) 521097 Parker, Keith K. (Keith Krom) 521098 Royal Society of Chemistry (Great Britain) 60276 bib-zmy-snn lcc 351113 380633 0 0 lcc 0 0 GENERAL KIMC KIMC OPEN 2025-02-17 667.63 QP517 C45 E96A 2011 00011238439 2019-08-20 00:00:00 1 667.63 BOOKGEN