A systematic review on the effects of leptin on the development of benign prostatic hyperplasia / by Mariam Shahida binti Saupi

By:

Mariam Shahida Saupi [author]

Contributor(s):

Language: English Kuantan, Pahang : Kulliyyah of Medicine, International Islamic University Malaysia, 2021Description: xi, 34 leaves : illustrations ; 30 cmContent type:

text

Media type:

unmediated
computer

Carrier type:

volume
online resource

Subject(s):

Genre/Form:

Theses, IIUM local

LOC classification:

RC899

Online resources:

Click here to access online

Dissertation note: Thesis (MMDSC)--International Islamic University Malaysia, 2021. Summary: Benign prostatic hyperplasia (BPH) is a debilitating disease commonly affected in elderly men. Obesity is an established risk factor for the development of BPH. Leptin, an appetite-regulating hormone, is associated with obesity and has been suggested to play a role in the proliferation, migration, and invasion of various cancer tissues. However, there were still insufficient studies that systematically review the existing literature on leptin and its effects on the prostate's benign tumour. Hence, the purpose of the present article was to conduct a systematic literature review to investigate the role of leptin and its receptor in the development of BPH. This review article is guided by the publication standard PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). We selected the published reports using three leading databases, namely PubMed, Scopus, and Science Direct. Two hundred and seven papers were retrieved, 24 eligible studies identified, 16 of these were included after the quality appraisal. This review has four main themes based on the thematic analysis: 1) serum leptin level 2) leptin tissue expression 3) leptin receptor expression and 4) serum leptin and prostate-specific antigen (PSA) level. In summary, most of the studies showed that serum leptin and leptin expression on tissue do not correlate with BPH development, its receptors do not exhibit a clear association with BPH progression and there was no association between leptin level and PSA. However, we observed that the pool of data on this issue is still limited. More studies are required to explore leptin's role as a potential biomarker of BPH and uncover its use in the therapeutic arena.

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Holdings ( 1 )
Title notes ( 5 )

Holdings
Cover image	Item type	Current library	Home library	Collection	Shelving location	Call number	Materials specified	Vol info	URL	Copy number	Status	Notes	Date due	Barcode	Item holds	Item hold queue priority	Course reserves
	Thesis	Indera Mahkota Campus Library	Indera Mahkota Campus Library	IIUM Thesis Collection	Close Access Shelf	t RC 899 M332S 2021 (Browse shelf(Opens below))				1	Reference Only			11100436810

Abstracts in English and Arabic.

"A systematic review submitted in fulfilment of the requirement for the degree of Master of Medical Sciences." --On title page.

Thesis (MMDSC)--International Islamic University Malaysia, 2021.

Includes bibliographical references (leaves 28-34).

Benign prostatic hyperplasia (BPH) is a debilitating disease commonly affected in elderly men. Obesity is an established risk factor for the development of BPH. Leptin, an appetite-regulating hormone, is associated with obesity and has been suggested to play a role in the proliferation, migration, and invasion of various cancer tissues. However, there were still insufficient studies that systematically review the existing literature on leptin and its effects on the prostate's benign tumour. Hence, the purpose of the present article was to conduct a systematic literature review to investigate the role of leptin and its receptor in the development of BPH. This review article is guided by the publication standard PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). We selected the published reports using three leading databases, namely PubMed, Scopus, and Science Direct. Two hundred and seven papers were retrieved, 24 eligible studies identified, 16 of these were included after the quality appraisal. This review has four main themes based on the thematic analysis: 1) serum leptin level 2) leptin tissue expression 3) leptin receptor expression and 4) serum leptin and prostate-specific antigen (PSA) level. In summary, most of the studies showed that serum leptin and leptin expression on tissue do not correlate with BPH development, its receptors do not exhibit a clear association with BPH progression and there was no association between leptin level and PSA. However, we observed that the pool of data on this issue is still limited. More studies are required to explore leptin's role as a potential biomarker of BPH and uncover its use in the therapeutic arena.